By Rodrick Wallace,Deborah Wallace
This ebook, according to released stories, takes a distinct standpoint at the 30-year cave in of pharmaceutical productiveness within the look for small molecule “magic bullet” interventions. The relentless escalation of inflation-adjusted price consistent with authorized drugs within the usa — from $200 million in 1950 to $1.2 billion in 2010 — has pushed giants to, at top, slavish imitation in drug layout, and at worst, abandonment of study and embracing of common fraud in patron marketing.
The ebook adapts formalism throughout a couple of disciplines to the tactic for layout of mutilevel interventions, focusing first on molecular, mobile, and bigger scale examples, after which extending the argument to the simplifications supplied by way of the dominant position of social and cultural buildings and techniques in person and inhabitants styles of health and wellbeing and illness.
In position of “magic bullets”, we needs to now follow “magic techniques” that act throughout either the size and point of association. This e-book offers an introductory roadmap to the hot instruments that might be wanted for the layout of such strategies.
- Beyond Magic Bullets
- Expanding the Theory
- Dynamic ‘Regression Models’
- An Evolutionary Excursion
- Example: psychological Disorders
- Example: Protein Folding
- Example: Glycome Determinants
- Example: Glycan/Lectin common sense Gates
- Example: IDP common sense Gates
- History and Health
- Beyond Glasperlenspiel
- Mathematical Appendix
Readership: Undergraduate, graduate, researchers and execs in biomathematics, biostatistics, mathematical modeling, complicated structures and pharmaceuticals.
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Extra info for A Mathematical Approach to Multilevel, Multiscale Health Interventions:Pharmaceutical Industry Decline and Policy Response
A Mathematical Approach to Multilevel, Multiscale Health Interventions:Pharmaceutical Industry Decline and Policy Response by Rodrick Wallace,Deborah Wallace